Research

RESEARCH

Positron emission tomography (PET) is a fast-growing imaging modality mainly used in oncology. Our research projects covers areas from technical and clinical validation of a novel PET platform to automatic quantification of images for prognostication and evaluation of treatment response in oncology. The overall aim is to realize the true clinical potential of PET.

 

The specific aims of the projects are:

 

  • to perform a comprehensive validation of a modern PET platform including technical validation, clinical validation and health economy assessment
  • to develop and validate new imaging biomarkers in PET-CT based on deep learning in patients with prostate cancer

 

Currently, we have 1 GE Discovery 690 and 4 GE Discovery MI. The hospital has two cyclotrons.

 

We also conduct research in general nuclear medicine and internal dosimetry.

PUBLICATIONS (last 3 years)

Lindgren Belal S, Sadik M, Kaboteh R, Enqvist O, Ulén J, Poulsen MH, Simonsen J, Hoilund-Carlsen PF, Edenbrandt L, Trägårdh E. Deep learning for segmentation of 49 selected bones in CT scans: First step in automated PET/CT-based 3D quantification of skeletal metastases. Eur J Radiol 2019 Apr;113:89-95.


Bjöersdorff M, Oddstig J, Karindotter-Borgendahl N, Almquist H, Zackrisson S, Minarik D, Trägårdh E. Impact of penalizing factor in a block-sequential regularized expectation maximization reconstruction algorithm for 18F-fluorocholine PET-CT regarding image quality and interpretation. EJNMMI Phys 2019 Mar 21;6(1):5.


Sadik M, Lind E, Polymeri E, Enqvist O, Ulén J, Trägårdh E. Automated quantification of reference levels in liver and mediastinal blood pool for the Deauville therapy response classification using FDG-PET/CT in Hodgkin and non-Hodgkin lymphomas. Clin Physiol Funct Imaging. 2018 Oct 3. doi: 10.1111/cpf.12546.

 

Kjölhede H, Almquist H, Lyttkens K, Bratt O. Pre-treatment 18F-choline PET/CT is prognostic for biochemical recurrence, development of bone metastasis, and cancer specific mortality following radical local therapy of high-risk prostate cancer. Eur J Hybrid Imaging. 2018;2(1):16. doi: 10.1186/s41824-018-0034-2. Epub 2018 Aug 7.

 

Sundlöv A, Gustafsson J, Brolin G, Mortensen N, Hermann R, Bernhardt P, Svensson J, Ljungberg M, Tennvall J, Sjögreen Gleisner K. Feasibility of simplifying renal dosimetry in 177Lu peptide receptor radionuclide therapy. EJNMMI Phys. 2018 Jul 5;5(1):12. doi: 10.1186/s40658-018-0210-2.

 

Reza M, Kaboteh R, Sadik M, Bjartell A, Wollmer P, Trägårdh E. A prospective study to evaluate the intra-individual reproducibility of bone scans for quantitative assessment in patients with metastatic prostate cancer. BMC Med Imaging. 2018 May 4;18(1):8. doi: 10.1186/s12880-018-0257-5.

 

Jönsson A, Fedorowski A, Engström G, Wollmer P, Hamrefors V. High prevalence of undiagnosed COPD among patients evaluated for suspected myocardial ischaemia. Open Heart. 2018 Oct 25;5(2):e000848. doi: 10.1136/openhrt-2018-000848.

 

Oddstig J, Martinsson E, Jögi J, Engblom H, Hindorf C. Differences in attenuation pattern in myocardial SPECT between CZT and conventional gamma cameras. J Nucl Cardiol. 2018 May 23. doi: 10.1007/s12350-018-1296-6.

 

Pratt BE, Hindorf C, Chittenden SJ, Parker CC, Flux GD. Excretion and whole-body retention of radium-223 dichloride administered for the treatment of bone metastases from castration resistant prostate cancer. Nucl Med Commun. 2018 Feb;39(2):125-130. doi: 10.1097/MNM.0000000000000783.

 

Kaboteh R, Minarik D, Reza M, Sadik M, Trägårdh E. Evaluation of changes in Bone Scan Index at different acquisition time-points in bone scintigraphy. Clin Physiol Funct Imaging. 2018 Apr 6. doi: 10.1111/cpf.12518. 

 

Jönsson L, Stenvall A, Mattsson E, Larsson E, Sundlöv A, Ohlsson T, Hindorf C. Quantitative analysis of phantom studies of 111In and 68Ga imaging of neuroendocrine tumours. EJNMMI Phys. 2018 Feb 20;5(1):5. doi: 10.1186/s40658-018-0204-0.

 

Lindgren Belal S, Sadik M, Kaboteh R, Hasani N, Enqvist O, Svärm L, Kahl F, Simonsen J, Poulsen MH, Ohlsson M, Høilund-Carlsen PF, Edenbrandt L, Trägårdh E. 3D skeletal uptake of 18F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer. EJNMMI Res. 2017 Dec;7(1):15. doi: 10.1186/s13550-017-0264-5. Epub 2017 Feb 16.

 

Oddstig J, Hindorf C, Hedeer F, Jögi J, Arheden H, Hansson MJ, Engblom H. The radiation dose to overweighted patients undergoing myocardial perfusion SPECT can be significantly reduced: validation of a linear weight-adjusted activity administration protocol. J Nucl Cardiol. 2017 Dec;24(6):1912-1921. doi: 10.1007/s12350-016-0628-7.

 

Andersson M, Mattsson S, Johansson L, Leide-Svegborn S. A biokinetic and dosimetric model for ionic indium in humans.

 Phys Med Biol. 2017 Jul 20;62(16):6397-6407. doi: 10.1088/1361-6560/aa779f.

 

Kollberg P, Almquist H, Bläckberg M, Cwikiel M, Gudjonsson S, Lyttkens K, Patschan O, Liedberg F. [18F]Fluorodeoxyglucose-positron emission tomography/computed tomography response evaluation can predict histological response at surgery after induction chemotherapy for oligometastatic bladder cancer. Scand J Urol. 2017 Aug;51(4):308-313. doi: 10.1080/21681805.2017.1321579. Epub 2017 May 22.

 

Engblom H, Xue H, Akil S, Carlsson M, Hindorf C, Oddstig J, Hedeer F, Hansen MS, Aletras AH, Kellman P, Arheden H. Fully quantitative cardiovascular magnetic resonance myocardial perfusion ready for clinical use: a comparison between cardiovascular magnetic resonance imaging and positron emission tomography. J Cardiovasc Magn Reson. 2017 Oct 19;19(1):78. doi: 10.1186/s12968-017-0388-9.

 

Murray I, Chittenden SJ, Denis-Bacelar AM, Hindorf C, Parker CC, Chua S, Flux GD. The potential of 223Ra and 18F-fluoride imaging to predict bone lesion response to treatment with 223Ra-dichloride in castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2017 Oct;44(11):1832-1844. doi: 10.1007/s00259-017-3744-y. Epub 2017 Jun 13.

 

Trägårdh E, Tan SS, Bucerius J, Gimelli A, Gaemperli O, Lindner O, Agostini D, Übleis C, Sciagrà R, Slart RH, Underwood SR, Hyafil F, Hacker M, Verberne HJ. Systematic review of cost-effectiveness of myocardial perfusion scintigraphy in patients with ischaemic heart disease: A report from the cardiovascular committee of the European Association of Nuclear Medicine. Endorsed by the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2017 May 1;18(8):825-832

 

Barrington SF, Kirkwood AA, Franceschetto A, Fulham MJ, Roberts TH, Almquist H, Brun E, Hjorthaug K, Viney ZN, Pike LC, Federico M, Luminari S, Radford J, Trotman J, Fosså A, Berkahn L, Molin D, D'Amore F, Sinclair DA, Smith P, O'Doherty MJ, Stevens L, Johnson PW.PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study. Blood. 2016 Mar 24;127(12):1531-8. doi: 10.1182/blood-2015-11-679407. Epub 2016 Jan 8.

 

Reza M, Jones R, Aspegren J, Massard C, Mattila L, Mustonen M, Wollmer P, Trägårdh E, Bondesson E, Edenbrandt L, Fizazi K, Bjartell A. Bone Scan Index and Progression-free Survival Data for Progressive Metastatic Castration-resistant Prostate Cancer Patients Who Received ODM-201 in the ARADES Multicentre Study. Eur Urol Focus. 2016 Dec;2(5):547-552. doi: 10.1016/j.euf.2016.01.005.

 

Reza M, Ohlsson M, Kaboteh R, Anand A, Franck-Lissbrant I, Damber JE, Widmark A, Thellenberg-Karlsson C, Budäus L, Steuber T, Eichenauer T, Wollmer P, Edenbrandt L, Trägårdh E, Bjartell A. Bone Scan Index as an Imaging Biomarker in Metastatic Castration-resistant Prostate Cancer: A Multicentre Study Based on Patients Treated with Abiraterone Acetate (Zytiga) in Clinical Practice. Eur Urol Focus. 2016 Dec;2(5):540-546. doi: 10.1016/j.euf.2016.02.013. 

 

Anand A, Morris MJ, Kaboteh R, Reza M, Trägårdh E, Matsunaga N, Edenbrandt L, Bjartell A, Larson SM, Minarik D. A Preanalytic Validation Study of Automated Bone Scan Index: Effect on Accuracy and Reproducibility Due to the Procedural Variabilities in Bone Scan Image Acquisition. J Nucl Med. 2016 Dec;57(12):1865-1871.

 

Andersson M, Johansson L, Mattsson S, Minarik D, Leide-Svegborn S. ORGAN DOSES AND EFFECTIVE DOSE FOR FIVE PET RADIOPHARMACEUTICALS. Radiat Prot Dosimetry. 2016 Jun;169(1-4):253-8. doi: 10.1093/rpd/ncw033. 

 

Anand A, Morris MJ, Larson SM, Minarik D, Josefsson A, Helgstrand JT, Oturai PS, Edenbrandt L, Røder MA, Bjartell A. Automated Bone Scan Index as a quantitative imaging biomarker in metastatic castration-resistant prostate cancer patients being treated with enzalutamide. EJNMMI Res. 2016 Dec;6(1):23. doi: 10.1186/s13550-016-0173-z.

 

Akil S, Sunnersjö L, Hedeer F, Hedén B, Carlsson M, Gettes L, Arheden H, Engblom H. Stress-induced ST elevation with or without concomitant ST depression is predictive of presence, location and amount of myocardial ischemia assessed by myocardial perfusion SPECT, whereas isolated stress-induced ST depression is not. J Electrocardiol. 2016 May-Jun;49(3):307-15. doi: 10.1016/j.jelectrocard.2016.03.016.

 

Leide-Svegborn S, Ahlgren L, Johansson L, Mattsson S. Excretion of radionuclides in human breast milk after nuclear medicine examinations. Biokinetic and dosimetric data and recommendations on breastfeeding interruption. Eur J Nucl Med Mol Imaging. 2016 May;43(5):808-21. doi: 10.1007/s00259-015-3286-0.